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A hub circRNA regulating system ended up being set up based on the co-expressed DEmiRNAs and DEmRNAs owning contrary correlation with the clinical qualities, success and macrophage infiltration amount. A gene trademark based on the DEmRNAs in hub netwophage fraction predicted good survival for HCC. A circRNA-miRNA-mRNA network was constructed by 27 macrophage relevant DEmRNAs, 21 DEmiRNAs, and 15 DEcircRNAs. Among this network, the phrase of hsa-miR-139-5p was adversely correlated with CDCA8, KPNA2, PRC1 or TOP2A.