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ADHD Stimulant Medication Stimulants aid in the treatment of 70 percent to 80% children and adults suffering from ADHD. They ease symptoms by increasing dopamine and norepinephrine levels. These medications start working in 30 to 45 minutes and last between 3 and 6 hours. The medicines are available in chewable or liquid tablet form. Your doctor may prescribe non-stimulant drugs in conjunction with stimulants. These include