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Does ADHD Medication Work? When someone gets a prescription for ADHD medication, they often think about whether the medication will work and how long it will last. Here are some straightforward solutions. The stimulants alter the levels of brain chemicals that transmit messages regarding focus and activity. They include dopamine and norepinephrine. They are often considered to be the first-line treatment option for adults suffering from ADHD. 1. Stimulants Stimulants are the most frequently prescribed drugs to treat ADHD. They alter the activity of neurot