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Thus, suppressing osteoclastogenesis and bone-resorbing purpose is a successful therapeutic target for bone tissue conditions. Betulinic acid (BA), an all-natural plant-derived pentacyclic triterpenoid element, is well known to possess numerous pharmacological and biochemical properties including anti-inflammatory, anticancer, and antiadipogenic activity. Nevertheless, the effect of BA on osteoclast differentiation and function in bone metabolism has not been de