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This effect was consistent throughout all of the years included in this study with the smallest protective effect observed in 2018 (2012 risk ratio = 1.27 (95% CI 1.23, 1.32); 2018 risk ratio 1.03 (95% CI 1.01, 1.05). These findings suggest that opioids prescribed in combination with antibiotics in the hospital setting are protective against the development of OUD at later time points following hospital discharge. As health care improves and more people work into later age, it is important to understand what impacts open-mindedness has on decision-making. T
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