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Moreover, we also demonstrated that p16 removal inhibited OVX-induced oxidative stress and bone tissue cellular senescence, such as for instance an important decline in reactive oxygen species levels, up-regulation of superoxide dismutase 1 and 2 protein expression amounts, and reduced total of the portion of β-galactosidase-positive osteocytes and p21 protein expression levels in bony tissue. Our results indicate that p16 removal can possibly prevent estro
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