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We thank Dr. Yu et al for their thoughtful and constructive comments on our recent report about angiographic characteristics in moyamoya disease (MMD) with the p.R4810K variant. We really appreciate the interesting three highlights they have summarized. This article is protected by copyright. All rights reserved.BACKGROUND The role of intracranial occlusive disease in cognitive impairment and dementia is unclear and has not been well studied. METHODS Thirty-two consecutive patients (13 males, aged 54±12 years) with asymptomatic steno-occ