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This model had been internally validated using bootstrapping. The C-index associated with SHIFT model was 0.81 (95% CI 0.77-0.83) while the C-index regarding the ESC model (performed in a subgroup of 349 HCM customers) was 0.77 (95% CI 0.73-0.81) (p=0.246). CONCLUSION The SHIFT design may possibly provide prognostic worth and play a role in the medical decision-making procedure for ICD implantation for primary prevention of SCD. Depression is a highly heterogeneous s