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Coal gasification wastewater (CGW) contains high concentration phenols which lead to poor anaerobic biodegradability and resource utilization. In this paper, new insights to improve synthetic CGW anaerobic degradation with the help of graphene under co-digestion conditions were investigated. Batch tests showed that with the addition of graphene dosage of 10 g/L and glucose as a co-substrate with chemical oxygen demand (COD) concentration of 2000 mg/L, the average COD concentration decreased from 3995 mg/L on day 1 to 983 mg/L on day 12.