https://www.selleckchem.com/pr....oducts/d-luciferin.h
Small-conductance Ca -activated potassium (SK) channels are activated exclusively by increases in intracellular Ca that binds to calmodulin constitutively associated with the channel. Wild-type SK2 channels are activated by Ca with an EC value of ~0.3μmol/L. Here, we investigate hydrophobic interactions between the HA helix and the S4-S5 linker as a major determinant of channel apparent Ca sensitivity. Site-directed mutagenesis, electrophysiological recordings and molecular dynamic (MD) simulations were utilized. Mutations that decr
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