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A favorable outcome was observed in 58% of all patients at 46 months median follow-up, with adequate disease-specific treatment. The prevalence of intracranial mass lesions in Filipino patients with HIV is 2.2%. The most common etiology was toxoplasmic encephalitis followed by tuberculosis. These findings are substantially different from other findings reported in the literature and should be considered in formulating guidelines for the Filipino population. The prevalence of intracranial mass lesions in Filipino patients with HIV is 2.2