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This review discusses the major factors influencing the disparities in CRC and also focuses on factors such as treatment response, family history, and screening that potentially contribute to the racial/ethnic disparities in CRC.Phytochemicals are derived from natural sources and identified to be the potential inhibitors of colorectal cancer (CRC) progression. Phytochemicals are also recognized as inhibitors of hallmarks of cancer such as invasion, migration, proliferation, angiogenesis, tumor escape immune surveillance, metasta