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This study assessed the therapeutic efficacy of postoperative magnetic resonance (MR)-guided interstitial I seed implantation for treatment of oral and maxillofacial malignant tumors. A total of 127 patients with oral or maxillofacial malignant tumors were included in this study who received interstitial I treatment after the surgery resection. Before implantation, all the patients received MR scans to assess the lesion scope, extent, and nature. I implantation target regions were based on the pre-operative imaging. I seeds were delive