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Conclusion The treadmill exercise having neuroprotective effects in SNpc and corpus striatum has improved MPTP connected with motor deficits. Its considered as a non-pharmacological tool when it comes to handling of PD.Objectives Silibinin, as an herbal compound, has anti-cancer task. Because of reduced solubility of silibinin in liquid and the body liquids, it had been encapsulated in polymersome nanoparticles as well as its effects were evaluated on pancreatic disease cells and cancer stem c