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Most Effective ADHD Medication For Adults Many adults report that taking medication helps them focus, feel calmer and improve their relationships. Medicines can also help with other treatment methods like psychotherapy. Adults who suffer from ADHD are more likely to benefit from stimulants. They include amphetamine and methylphenidate compounds. Adults may take long-acting medicines that are slow-acting but last between 3 and 6 hours or short-acting medication several times per day. Stimulants Stim