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There is a need to recognize the underlying pattern so that appropriate genetic counseling, if any, can be provided to such patients. In this article, we briefly review the available literature to decipher if any of the associated syndromes with polyostotic FD (being the dominant clinical feature) are known to have associations which explain the above findings. There is a need to recognize the underlying pattern so that appropriate genetic counseling, if any, can be provided to such patients. Denosumab, a monoclonal antibody that inhibi