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Therefore, the recognition of novel representatives for particular TNBC targeting and treatment is desperately required. Here, by integrating cell-SELEX (Systematic advancement of Ligands by EXponential enrichment) when it comes to certain recognition of TNBC cells with high-throughput sequencing technology, we identified a panel of 2'-fluoropyrimidine-RNA aptamers binding to TNBC cells and their cisplatin- and doxorubicin-resistant types at reasonable nanomola