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Besides, BAEPS modulated a sexual hormone, when compared to the cancer tumors control group (P ⩽ .05). B. amyloliquefaciens 3MS 2017 selectively inhibited COX-2 in parallel with promising antioxidant properties. The curative characters of BAEPS were more encouraging than the prophylactic. Conclusion The anti-breast-cancer figures accompanied with an excellent protection margin is attributed to its inhibitory impact on cancer-growth-rate-limiting enzymes, estrogen production, COX-2 level and