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Nonetheless, its management remains largely unsatisfactory. The dysfunction of pulmonary macrophages adds significantly towards the development of allergic airway inflammation. It was reported that small extracellular vesicles produced by mesenchymal stromal cells (MSC-sEV) were able to show extensive therapeutic results in a few protected diseases. This study aimed to analyze the results of MSC-sEV on allergic airway irritation, plus the role of macrophages taking part in it. We successfully i