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Patients undergoing cancer treatment experience global stress and cancer-specific stress. Both types of stress are associated with a higher symptom burden. In this cross-sectional study, we used a comprehensive set of demographic, clinical, and symptom characteristics to evaluate their relative contribution to the severity of global and cancer-specific stress. Patients (N = 941) completed study questionnaires before their second or third cycle of chemotherapy. Consistent with our a priori hypothesis, we found both common and distinct ch