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Particularly, the levels of 5-HT and NE appeared to increase significantly (P less then 0.05) after AWE administration. At the same time, in vitro antioxidant experiments also revealed that AWE displayed better antioxidant activity. Collectively, these results suggest that AWE possesses good antidepressant activity, and these effects may be mediated by enhancing monoamine neurotransmitter content in the brain or antioxidant capacity to improve depression.Mushrooms are rich in various nutrients and secondary metabolites. In this study, t