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One of many major reasons attributed to this variation is hereditary mutation. Consequently, we aimed to anticipate the mutations within the spike protein (S) of the SARS-CoV-2 genomes available all over the world and analyze its impact on the antigenicity. Materials and practices Several research teams have generated whole genome sequencing data that are for sale in the public repositories. A complete of 1,604 spike proteins had been obtained from 1,325 total genome and 279 p