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Ambient mass spectrometry is used for direct analysis and high-throughput screening in many fields. However, most researches are about qualitative analysis. Quantitative detection based on AMS only performs on standard compounds and the relative standard deviation is so large that the accuracy of the result is low. In this study, a hydrogen flame ion source with ultrasonic nebulizer as sampling unit was established to enable solid samples to extract, nebulize and quantitatively detect in situ, with high sensitivity. This device was use