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is the key for successful root canal treatment. The present study helps in choosing an appropriate irrigant that can ensure complete root canal debridement from all thirds, especially from the apical third of the root canal. How to cite this article Mankeliya S, Singhal RK, Gupta A, et al. A Comparative Evaluation of Smear Layer Removal by Using Four Different Irrigation Solutions like Root Canal Irrigants An In Vitro SEM Study. J Contemp Dent Pract 2021;22(5)527-531. The aim of this study was to determine the lateral pte