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The CHASMS conceptual model (Cascading Hazards to disAsters that are Socially constructed eMerging out of Social Vulnerability) interrogates the tension between local communities and the larger structural forces that produce social inequities at multiple levels, capturing how those inequities lead to cascading disasters. We apply the model to COVID-19 as an illustration of how underlying inequities give rise to foreseeable inequitable outcomes, emphasizing the U.S. experience. We offer Kenya and Puerto Rico as examples of cumulative effe