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Therefore, its of good relevance to reveal the components associated with endogenous fix failure brought on by the undesirable microenvironments in IVD. The purpose of this research would be to investigate the result of oxidative strain on the rat NPMSCs and its underlying process. Our outcomes demonstrated that oxidative stress inhibited cellular viability, induced apoptosis, and enhanced the production of reactive oxygen species (ROS) in NPMSCs. In addition, the results indicated that the a