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Mean age in the TRD group was 52.8 years versus 48.2 for MDD (P less then .001). Both groups were predominantly female (TRD 72.8% vs MDD 66.9%; P less then .001). Overall, the TRD group had greater costs than the MDD group, with 1.23 times (95% CI, 1.21-1.26; P less then .001) greater total cost on average over 1 year following index date. Within both groups, those with severe symptoms had greater total mean (SD) costs (TRD moderate $12,429 [$23,900] vs severe $13,344 [$22,895], P less then .001; low $12,220 [$31,864] vs severe $13