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To analyze muscle, endocrine, and immunological markers that influence frailty in older people assisted in primary care. Cross-sectional, analytical, and probabilistic study were linked to the institutional research "Integrated Health Care for Older People." The study population consisted of males and females aged 60years or more and assisted in primary health care. The research protocol included an interview and physical examination to evaluate the frailty criteria. Analysis of the following were done serum calcium and creatinine as muscle
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