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In this review, we portray the options and troubles of peptide-mediated treatment in chronic wounds biofilm management and how it could be clinically converted into a product.RNA helicase A (RHA) is a DExH-box helicase that plays regulatory roles in a number of cellular procedures, including transcription, translation, RNA splicing, editing, transport, and processing, microRNA genesis and maintenance of genomic stability. Its associated with virus replication