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Regrettably, you can find presently no Food And Drug Administration approved pharmacological treatments for METH substance abuse condition. As an alternative approach, we have previously investigated the usage of Adeno-associated viral (AAV) mediated gene transfer of an anti-METH monoclonal antibody. Here, we advance our approach by generating a novel anti-METH scFv-Fc fusion construct (7F9-Fc), packaged into AAV serotype 8 vector (called AAV-scFv-Fc), and tested i