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ADHD Medication - Stimulants Stimulants change how the brain releases chemicals that affect concentration. Doctors often start people with ADHD with stimulants, and then increase the dose that can help them. Antidepressants are also taken by those with ADHD (not just for depression). These medications work using the same chemical as stimulants but have less side negative effects. Stimulants Stimulants are the first medication doctors usually prescribe for ADHD. They boost levels of dop