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This reliable and economical MSI technique is expected to be used in understanding the precise chemical composition and transportation in small tissues, microorganisms, and single cells.The development of a highly efficient and stable catalyst for preferential oxidation of CO for the commercialization of proton-exchange membrane fuel cells has been a result of continuous effort. The main challenge is the simultaneous control of abundant active sites and interfacial reducibility over the catalyst CuxO/CeO2. Here, we report a strategy to