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The efficiency was similar to that seen with wild-type Tregs. After in vivo expansion, the converted CD4FOXP3 cells recapitulated the transcriptomic core signature for Tregs. These findings demonstrate that FOXP3 expression converts CD4+ T cells into functional Tregs capable of controlling severe autoimmune disease.Pear is one of the most important economic fruits worldwide. The productivity is often negatively affected by drought disaster, but the effects and adaptive mechanism of pear in response to drought stress has not been well und