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The aim of the present study was to define and contrast a explicative model of the relationship between the variables of quality of life that make up the KIDSCREEN-52 questionnaire. Methods A total of 1641 Colombian university students aged between 17 and 18 years (17.69 + 0.49 participated in this research (61.2% males and 38.8% females) analyzing the dimensions of the KIDSCREEN-52 quality of life questionnaire. A model of structural equation was made and adjusted (χ2 = 118.021; DF = 6; p less then 0.001; CFI = 0.953; NFI = 0.951; I