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More importantly, PLAGL2 expression reduced hepatoma cells' response to the anti-EGFR drug erlotinib. PLAGL2 knockdown enhanced the response to erlotinib. Conclusion This study reveals the pivotal role of PLAGL2 in HCC cell proliferation, metastasis, and erlotinib insensitivity. This suggests that PLAGL2 can be a potential novel therapeutic target of HCC. This article is protected by copyright. All rights reserved.Conventional wheat production utilizes fertilizers of various nitrogen forms. Sole ammonium nutrition has been shown to im