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However, the effect has not been extensively adopted, in part, as a result of limits associated with the accessibility to appropriate promoter-Nu reagents. We now have developed a stereospecific Ag(I)-promoted reaction for functionalizing NuBFr products to offer novel compositions of matter that could be beneficial in synthesis and medicinal biochemistry. With unhindered amine nucleophiles, structurally special [2.2.2]-bicycloamidines tend to be created. We also disc