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How a VC Can Affect Your Heart PVCs are common and can be experienced by a variety of people without causing any problems. If they occur often, PVCs may weaken your heart and increase the risk of heart failure. The heart's rhythm is usually controlled by a group of fibers that are located in the upper right-hand corner of your heart. This is called the sinoatrial nerve, or SA. Electrical signals travel from this node to the lower chambers of your heart or ventricles. Causes PVCs occur when the electrical impulse tha