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The toxicity profile was that expected with such treatments. Conclusion This study confirms a poor prognosis of metastatic NEC during post first-line treatment. LV5FU2-Dacarbazine or temozolomide-capecitabine chemotherapies allow a temporary clinical response for half of patients and/or a morphological response for a third of patients.Introduction Leonbergers are large-breed dogs believed to be predisposed to dilated cardiomyopathy, yet the normal echocardiographic measurements of these dogs are unknown. The aim of this study was to des