https://www.selleckchem.com/products/GDC-0449.html
RESULTS AS patients showed increased TCR diversity (CD4 P=7.8x10-6 , CD8 P=9.3x10-4 ), attributed to a significant reduction in the magnitude of peripheral T-cell expansions globally, and fewer patient T-cells expressed IFNγ (CD8 P=0.03) and TNFα (CD4 P=0.01, CD8 P=0.002) upon in vitro stimulation. Additionally, the CD8 TCR signature was altered, with significantly expanded EBV (P=0.03) and CMV-specific (P=0.02) clonotypes and increased incidence of public CD8 TCRs in HLA-B*27+ AS relative to controls, including homologous clonotypes m
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