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Finding the Best ADHD Medication For Adults Stimulants, such as methylphenidate (Ritalin) or amphetamine (Vyvanse) are effective to increase and regulate levels of brain chemicals. These drugs can cause weight fluctuations, tics, and sleep issues in certain people. Atomoxetine as well as certain antidepressants (like bupropion) are non-stimulant drugs that work slowly to help those suffering from ADHD symptoms. They increase a chemical within the brain known as norepinephrine, which helps increase concentrat