https://www.selleckchem.com/pr....oducts/PD-0332991.ht
chain AHLs enhances current knowledge regarding the variety of AHLs produced by this enzyme. These structural data are expected to serve as a molecular rationale for AHL synthesis by AhyI.Farnesoid X receptor (FXR) agonists can reverse dysregulated bile acid metabolism, and thus, they are potential therapeutics to prevent and treat nonalcoholic fatty liver disease. The low success rate of FXR agonists' RD and the side effects of clinical candidates such as obeticholic acid make it urgent to discover new chemotypes. Unfortunately
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