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The combination regimen achieved the superlative results in the antagonizing lead ac.-induced neurotoxicity via its antioxidant and anti-apoptotic activities. Although observational studies have suggested that prior intravitreal therapy may predict posterior capsule rupture (PCR) during cataract surgery, this finding is still controversial. To summarize current evidence on the association between prior intravitreal injection (IVI) and PCR during cataract surgery. A systematic literature search was performed up to October 27th, 2021. Poo