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were significantly downregulated in CCH group, relative to sham group, but they were significantly upregulated by NAM (p less then 0.05). These results indicate that NAM improves cognitive function in mice with CCH.General practitioners (GPs) provide primary care and advise their patients on which diagnostic and therapeutic pathways they judge most appropriate. For patients with functional neurological disorders (FND), receiving a proper explanation of diagnosis by their GP from the very beginning may drastically improve prognosis. No