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To talk about space, spoken languages rely on arbitrary and categorical forms (e.g., left, right). In sign languages, however, the visual-spatial modality allows for iconic encodings (motivated form-meaning mappings) of space in which form and location of the hands bear resemblance to the objects and spatial relations depicted. We assessed whether the iconic encodings in sign languages guide visual attention to spatial relations differently than spatial encodings in spoken languages during message preparation at the sentence level. Using