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In a xenograft model, the identified small-molecule inhibitors induced changes in the epithelial mesenchymal transition, which affected the progression of CSCC.Conclusion EphB2 small-molecule inhibitors had anti-CSCC effects, establishing a solid theoretical basis for clinical research.Complement is a part of the innate immune system with a critical role in host defense. Although essential for survival, when dysregulated or excessively triggered complement activation can cause tissue damage and drive inflammatory and immune disorders. T
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