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10 compounds were predicted to have therapeutic potentials for treating UC. Among them, we selected meclofenamic acid to identify its therapeutic effect on UC treatment by animal experiments. The current study comprehensively analyzed the DEGs and immune infiltration in UC, as well as screened for potential agents for UC treatment. The current study comprehensively analyzed the DEGs and immune infiltration in UC, as well as screened for potential agents for UC treatment. Ionizing radiation (IR) induces injuries to the hematopoietic and in