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Refractory angina is agrowing and major health-care problem affecting millions of patients with coronary artery disease worldwide. The Coronary Sinus Reducer (CSR) is adevice that may be considered for the relief of symptoms of refractory angina. It causes increased venous pressure leading to adilatation of arterioles and reduced arterial vascular resistance in the sub-endocardium. This study describes the 5‑year Dutch experience regarding safety and efficacy of the CSR. One hundred and thirty-two patients with refractory angina were tre
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