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To investigate the association between medication use and long-term all-cause mortality in a Brazilian stroke cohort. Both ischemic and hemorrhagic stroke were evaluated. Medication use was assessed as never, only pre-stroke, only post-stroke, and continuous use. We evaluated anti-hypertensives, anti-diabetics, lipid-lowering drugs, anti-platelets, and anti-coagulants. Cox regression models were adjusted for sociodemographic and cardiovascular risk factors. Among 1173 incident stroke cases (median age 68; 86.8% were ischemic, 70% first-ev