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Finding the Best ADHD Medication For Adults Stimulants, such as methylphenidate (Ritalin) or amphetamine (Vyvanse) can be used quickly to increase and stabilize levels of brain chemicals. These drugs can cause a loss of appetite, sleep problems, weight changes and tics in some people. Atomoxetine, as well as certain antidepressants, such as bupropion, are all non-stimulants which slow down the treatment of ADHD symptoms. They boost norepinephrine, which is a chemical in the brain that helps contr