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Medications and Therapy For ADHD A combination of therapy and medication can help to manage ADHD symptoms. treat the brain and therapy helps people develop techniques and manage. Stimulants, like the methylphenidate and lisdexamfetamine, boost levels of two chemical substances in the brain, which transmit messages between cells. This improves the level of attention, impulse control, and motivation. The stimulants can have adverse effects, including insomnia, a loss of appetite and a rise in blood pressure and heart rate. Stimulants Stimulants are typically the fi